Wednesday, May 5, 2010

Melanoma Not Caused by Early Ultraviolet (UVA) Light Exposure, New Fish Experiments Show



(I'm posting this article until someone else has a post they want to put up. Please feel free to replace it.)

"UVA exposure is unlikely to have contributed to the rise in the incidence of melanoma over the past 30 years, the researchers conclude, because the fish model had been the only animal model to indicate a connection between exposure to UVA at a young age and later development of melanoma". (The 1993 experiment could not be replicated in mammalian models of melanoma)

Our data refute the only direct evidence that UVA causes melanoma, which is not to say that UVA is harmless....... UVA is just not as dangerous as we thought because it doesn't cause melanoma....

UVA is a carcinogen responsible for squamous cell carcinomas that also causes premature aging of the skin and suppresses the immune system. It's also possible, the authors note, that long-term chronic exposure to UVA can hasten the progression to malignancy of melanocytes in the skin that are already on the path to becoming melanoma.

The thought was that people who used sunscreen stayed out in the sun longer, absorbing a higher dose of UVA, causing a higher risk for melanoma" Mitchell said. Most sunscreens now protect against UVA. However, the increase in the incidence of melanoma has been thought to be partly attributable to childhood exposure to UVA back when sunscreens blocked only UVB. That's unlikely, given the new results...

UVB exposure damages DNA directly, while UVA is thought to inflict its damage indirectly by inducing melanin free radicals that react with DNA to form oxidative damage that leads to melanoma. Previous studies had shown a correlation between melanin radical formation and melanoma in the UVA range of the solar spectrum. Since Mitchell and colleagues found no connection between UVA and melanoma, they note that the role of melanin free radicals in this disease is brought into question." http://www.sciencedaily.com/releases/2010/05/100504155419.htm

66 comments:

Chloe said...

What surprised me most about this, is that it took 30 years to discredit the original finding - that, and it's also surprising that this finding was originally only made on fish, because they couldn't replicate the results on mammals.

Now, this 'fish' experiment has contradicted and replaced the original 'fish' experiment - 30 years of what we've believed about melanoma probably wrong.

Solar said...

Chloe,

thats one of the things that I love about science.....it will catch up to the truths sooner of later......it is always amending this or that.....with the tools that they have now...they are not off by much any more.!

Solar said...

Mary,

Feliz 5 de Mayo & to all u pinks.......resting today and reading...nice sunny and cool day.....Coreen it's purrrrrrfect out side.!!

Carol said...

Interesting study Chloe. If anyone has problems with skin cancer, I still wouldn't rush out for a suntan. My dad died a pretty nasty death from skin cancer. He was a red head and spent lots of time in the sun. I'm not as careful as I should be. I never go out with the purpose of tanning but I do forget my sunscreen and spend lots of time outside.

Carol said...

JP Morgan's CEO is afraid of our Elizabeth Warren. He refused to debate her on that consumer protection agency. This describes her well.

"Elizabeth is at her best when she deploys that razor-sharp eloquence in defense of the American consumer. Some of her ideas are controversial, but we always listen because her powerful intellect and plainspoken articulation prove to be an irresistible combination. Of all the victims of the damage done in the past two years by the financial meltdown and the ensuing economic downturn, consumers have suffered the most. But that may soon come to an end if Elizabeth has her way and Congress establishes a new and independent consumer watchdog for financial products. I say high time"

http://curiouscapitalist.blogs.time.com/2010/05/04/why-jamie-dimon-is-afraid-of-elizabeth-warren/?xid=huffpo-direct

Carol said...

I had this guy from some prison or jail in California call to ask for some medical info on one of our inmates. In the course of our conversation he said that inmates over there could get a sex change operation if they desired. I told him I wouldn't even treat toe nail fungus if it isn't causing any serious medical problems. I also told him I understood why California is in such serious financial trouble.

Solar said...

Carol,

I do like E. Warren a lot...but don't know what she can do against a Giethner or summer typw...they run the shows for the corps....our entire system is run as a fraud.....

1). Accounting Fraud: Last year, America’s leading banks were insolvent. They had tens or hundreds of billions in losses on their books, and the only way to wipe those losses out would be to either a) own up to the mess, raise enormous amounts of money on top of all the bailout money; or b) get out a big fat eraser, and wipe those losses off the books as if they never existed. The first option was nice and all, but a real hassle. So Geithner and Larry Summers chose Door Number Two: Accounting Fraud. They forced the FASB to accept a rule-change in the accounting methodology called “mark-to-model” which let banks decide how much their assets were worth, rather than letting the markets decide.

This is how that goes....lets say that my whole company is worth 5 dollars...thats it just 5.....what the mark to model lets me do it to say that it is worth 5 m illiion dollars.....so that gives me a net worth of k mil.......a magic eraser just erased 5 mil in debts...now my portfolio looks pretty good, and i can borrow a lot of $ to give myself a huge bonus......

Coreen said...

While there is absolutely no doubt in my mind
that Elizabeth Warren would surpass anything
Jamie Dimon or any other of the Masters of the Universe could possibly utter in a real discussion...this agency is her baby, she knows it inside & out & would only expose just how little they really know... in the past any time she was asked to explain any subject (usually in the past as relates to bankruptcy issues) she excelled.....

They should fear her & her ideas, which is precisely why...I am convinced that even if the
watered down version of the CFPA actually gets
included & passed in the pending bill...the powers that be will make sure she is not involved in it.....Hope I am wrong, but....

Coreen said...

Oh, & Solar, if you are close by...today was
beautiful, but this evening is exquisite.....

Coreen said...

Mark to model...think Enron fiasco....
allows the illusion of liquidity....

Ivy Green said...

Here's me, a lucky early-melanoma-detection survivor...

Fish schmish. See your dermatologist for a full body skin check every year. Every six months if you've had skin cancer, or have an immediate blood relative who had it. Melanoma is a virulent killer. I came so close to not dodging that bullet.

Coreen said...

or for us mere mortals...allows the illusion
that the there is available cash to back them
up....

Solar said...

Coreen,

Yes it has been a great day, and going to be an exquisite evening......just the right kind of night to dance too.....ready? Chloe never did answer me when I sent her B. Middler to ask for me.....I guess that she was to tired after dancing around with Emma all day.....Carol was to tired Jan is out out town Maria is working, and Ivy....well she can't get out of that there dang man cave long enough to dance...and her shoulder hurts...how is she going to dip me.......that leaves...........

Ivy Green said...

Thanks for the post, Chloe. Hit home.

jan said...

Hi folks, I am back. It is going to take me a couple of days to catch up on the postings and comments. It is amazing how much information is generated in 4 days.

We had a great mini vacation. I will write more later.

Ivy Green said...

Solar,
Shoulder doing better. I had acupuncture for the first time on Monday.

Ivy Green said...

Carol,
Amazing discovery...some things cannot be dusted because the dust is what's holding them together.

Coreen said...

I am one of the lovers of the sun...did spend
a goodly amount of time early on soaking up those rays, but have not done so for a lot of years...though I must admit that like you Carol, I don't use sunscreen when I do something outside...

Such a shame that something that feels so so good, can have such a devastating effect on you...

Ivy, sorry to hear of your experience with skin cancer, but very happy that you are one
of the fortunate survivors....

Carol said...

I'm glad to see Warren's face front and center in the media again. That's always a good sign. It means her message is getting attention. I get nervous when I don't hear from her.

Coreen said...

You want to dance Solar.....

Try this.....gotta move when this is on...during law school we spent a lot of time at a place in Westport....they even had
a silver disco ball in the upstairs dance area

Boogie Oogie Oogie-A Taste of Honey

Coreen said...

Looks like Jan came home & snuck in for a minute...I'm sure you had a great getaway...hope we get to eavesdrop on some of
what you guys did....

Carol said...

My skin doesn't tolerate the sun anymore. I turn polka dotted. Some are brown, others white. I have wondered if I connect the dots would I get a message? Probably would....it would say wear sunscreen.

Chloe said...

Welcome back Jan! Hope you had a wonderful time.

Solar, What was that about Bette Middler - did I miss a post.

Chloe said...

Ivy, I agree: "Fish schmish. See your dermatologist for a full body skin check every year."

You can't be too careful, and the article did say that the sun can cause problems, regardless (also with the other type of skin cancer, that is caused by carcinogens)

I am so glad you dodged that bullet.

Chloe said...

" In the course of our conversation he said that inmates over there could get a sex change operation if they desired." I

Carol, I wouldn't have believed it unless I heard it with your own to ears.
One of the things that is so ridiculous about it, is that there will be those who would want to go to prison in order to get a sex change for free. Then what do they do, put them in the women's prison?

BTW, I am very impressed that you lost 7 pounds already, while I'm still here just thinking about it. You've inspired me to work a little harder on it.

Chloe said...

... uh, the part that really bothers me is that you have to feel hungry for a prolonged period of time in order to lose weight - and you're only losing weight during that period of feeling hunger, and for me that's almost like pain. It takes me a very long time to get to the point where I can talk myself into it, but I always feel great once I make the decision.

I've been eating healthy since we've been talking about it, but I've added too many goodies to the regiment, so now I'm just going to cut them out. I only want to lose about 6 or 7 pounds, so I should have that off in a few weeks.

Carol said...

Yes Chloe, I think they do have to house them with women once they have a sex change. The guy I was talking with did sound a little perturbed about it. He must have been involved with something like that. I just asked him if he was seeing more sick people coming into jail when he mentioned that.

Yes Jan, welcome home. Tell us about your honeymoon. How many pools did you do?

Carol said...

One trick Chloe is to go to the grocery store when you aren't in a snack mood. Early mornings are good for me. I pass those snacks right up and am really sorry about it later when I'm in the mood for one. I've been sorry every evening this week.

Carol said...

Chloe, I did go astray this week. We had Popeyes friend chicken and fixins for lunch the last two days at work. It was nurse's week and our nursing supervisor got admin to cough up for lunch for the nurses. Yesterday for one shift and today for the other. I ate it yesterday but was going home today to do my PB and J sandwich today. My usual path home was blocked by construction and finding a way around would have taken too long so I had to go back to work and do the fried chicken again. Hey, I tried.

Ivy Green said...

OMG. In Idol, Lady Gaga is decked out in Charlotte's Web.

Ivy Green said...

That was stupefying.

Carol said...

And I gained a pound. Damn that Popeyes!

Carol said...

I do like Lady Gaga. She eccentric, amazingly talented but sooo real. She truely loves her fans and give them her all.

Solar said...

Chloe,

U missed a few of my post...this was one of them....I was missing u a little and send a friend to ask U something.....

http://www.youtube.com/watch?v=nV5KGvQGaMY

Carol said...

Chloe, I have the advantage in that I have only me to feed. I can eat whatever without having to worry about pleasing anyone else. My evening meals have consisted of eating in shifts, cantaloupe first, then salad a little later, then broccoli, and then maybe some nut/raison mix I put together. Wouldn't work for a family.

Solar said...

Coreen,

Great song...danced to that a few times....I really did like to dance.....I never practiced...just learned when some poor girl said yes...they laughed at first ...but was a fast learner...thats a lie...my sister Maria did make me dance with her a lot......all of her 3 sons can be on dancing with the stars imo......

Ivy Green said...

Idol already a shocker and they're not even done...

Carol said...

Solar, with your love of dancing, do you ever watch DWTS?

Carol said...

and would you ever admit it??

Solar said...

No I don't watch it...just like sports...i loved/love playing them...but not as a spectator...U won't like my reasons.....

Solar said...

I do however like watching ballroom dancing....when it is on pbs sometimes....

Solar said...

"and would you ever admit it??"

Ha.! If i knitted sweater i would admit it....

Carol said...

I you could knit a sweater, you ought to admit it. I'd be impressed. Can you?

Solar said...

no, I can sew a little tho.

Carol said...

I can't believe those GOPers who want us to believe how tough they are on terror but defend allowing potential terrorist's the right to buy guns. What an example of cognitive dissonance and.... just plain old crazy.

I really don't understand why any terrorist thinks they can do any more harm to us than what has already been done to us by those who run this country. Terrorists, save your energy and just sit back and enjoy the show.

Carol said...

I still watch Dylan every day to get a real good dose of reality shock!

Carol said...

And isn't it crazy how all these experts get on TV and tell everyone, terrorists included, what this guy did wrong to get caught and how he could have done it better to be more successful??? Hmmmmm. I wonder if they are taking notes.

The person who impressed me the most is the citizen who reported this suspicious activity. That person is the hero. Many in the same city have just stepped over a dying person and kept walking.

It's, we the people, who will have to save this country. It's, we the people, who need to demand that our government does the right thing. It's, we the people, who need to clean out the schmucks in our government.

I guess it is not such a good idea to get all worked up before bedtime. Wonder what is on C2C tonight.

thornwil said...

Ivy,
Does your MD do Vit. D levels on you?? They are finding more and more people are deficient in Vit. D and that can cause all kinds of problems. Since you can't get in the sun, your's really needs to be monitored. Mine was below normal and I have to take 50,000U once a week plus I take what's in my calcium tabs every day.

jan said...

You guys are so kind to me. Just finished watching Idol. It is hard now to see anyone leave. They are all so good and they are so good together. I am biased. I do want Crystal to be the finalist or at least one of the top 2 finalists. The history of the show indicates that 2nd best is just as good as the Gold. I hope it will be Crystal and Lee as the final 2 contestants.

jan said...

What do you guys think of the pro with Erin on DWTS? I think he is not a good pro. She is working her butt off and he is just trying to PO Lynn (the judge).

jan said...

I have been most interested in the issue with the man from Pakistan who tried to blow up Times Square. I have worked very closely with a young mother and her child. She is from Pakistan and her uncle and his American-born wife adopted her when she was 14 and she moved to this country. She is now an American citizeb. She practices Islam. I have been working with her for about 9 months now. She is one of the sweetest young women I have worked with and one of the best mothers too. Interestingly, when I ask her about Pakistan, she "clams" up and changes the subject. The baby's father lives in a Northeast state (he is also from Pakistan) and was physically abusive toward her after she became pregnant. She keeps wanting to get back with him but her adoptive mother threatens to have nothing more to do with her if she goes back with him. Also, the adoptive mother tells her she will turn her into Child Protective Services if she returns to him. When I first heard the terrorist was from Pakistan I thought of him. From what this young woman tells me, her baby's father could be capable of this.

jan said...

I had to wait to watch Idol at home but watched DWTS in Colo. I think the judges were wrong in giving Nicole and her partner 9's. Their performance was a 10 in my book. Nicole already looks like a pro. It is just not fair for someone to be so beautiful and all that talent too. I did think Niecy had made the most improvement.Niecy adds so much with her humor. I hated to see Pam leave, but somebody had to go. Chad Ochonueve (my 1st translation of 85) is John's favorite - so I can't "wish" him off the show.

jan said...

John and I are terribly worried tonight. We picked Lobie up at the boarding place and she is not acting herself. She is not eating (her dry food) or drinking. I did offer her some chicken and she ate that but she usually woofs down her own food. She is just lying there. If she is still like this tomorrow we will take her to the vet. She is 12 years old. She has been sick with a stomach thing a couple of times so I am hoping that is all it is. She doesn't seem like she is in pain. But she just lays there and I have to work to get her to move. I wonder if dogs get depressed - that is how she is acting??

Carol said...

I don't know Jan. I need more information. I've heard of dog sulking for a while after you pick them up. She ate the chicken, that's a good sign. Maybe she already ate enough. Did they feed her at the other place before you picked her up? Have you ever left her there before and how did she act last time? How does she act when you say, lets go for a walk? Is her nose cool and wet? Did you see her poop nor pee.

This is kinda what I go thru when a security guard calls me at home from work to tell me there is something wrong with one of my inmates. Usually I don't ask the, is the nose cool and wet, question. He he.

If she hasn't perked up by this morning, I'd also bring her to the Doc. Hope everything is OK.

Carol said...

Jan, I think the judges do judge Nicole expecting a higher level of performance. I see them do that kind of thing all the time. They told them how good they were. I agree. She started at a high level and she has more of that kind of experience.

Carol said...

And Jan, I worry that we have lots of potential terrorists in our country, waiting. That's why I tried to tell them to leave it be, we have all the trauma we can take. There's also lots of anger stewing in this country. Lots of reasons for it.

I'm glad I have my green/water place to keep me centered. We have created a place here where we try to balance keeping up with the misery and finding our peace. We are all interested in politics, that's how we met, but we had to drop out to a certain extent to keep from going nuts.

Maybe this terrorist dude lost a bunch of money in his 401K or Mutual Fund. Didn't I hear that he did work in the financial area for a while? Do you think he might have seen some shit that really pissed him off?

Carol said...

I listened to a program on C2C about Wallstreet's Fantasy Finacial Scheme, last night. I can't believe the stuff they were doing is legal. They were creating fantasy stuff, didn't own any of it, selling this to school boards, encouraging them to borrow millions to buy it, telling them they could make big bucks, and then betting against them and making a killing on this. And this is legal??? People, I can't think of anything that is more of an example of fraud and highway robbery than this shit is. I can't believe anything even close to this is legal. I'm sorry but I'm ready to say lets reinstate the firing squad and put some of these creeps in front of it and I don't believe in the death penalty.

Carol said...

And I can't say that what this guy tried to do is any more horrible than what we're having done to us by so many others here and they don't call it terrorism. They call it smart business.

Carol said...

And if I was a criminal defense attorney today, I'd be trying to use what they consider legal for these shisters, as a way to influence a jury to acquit my clients of things that are so much less criminal in comparison. I'm sure I'd probably be overruled but I'd be trying.

Carol said...

And I believe that many of the bankers, Wallstreet guys, people in our government who have made or allowed laws that protect what's being done to us, and those big businesses that are avoiding the safety regulations to protect our environment, are TERRORISTS. They are terrorists in the worst possible way!

Chloe said...

Jan, I don't think Lobie is depressed (they act that way when they're sick - listless). If anything, she should be excited to be home. Definitely take her to the vet right away.

Chloe said...

Solar, I loved that Bette Middler song. Thanks.
I saw her in Vegas (.. it must have been like 36 years ago, or so - how time flies). We were there to see Johnny Carson, and he introduced her. She was still relatively unknown, but she sang a few songs (and danced) and she was amazing (I'll never forget it). You could tell she was going to be a big star - and of course, it wasn't long and she became one.
ps I've missed you too.

Chloe said...

"My evening meals have consisted of eating in shifts, cantaloupe first, then salad a little later, then broccoli, and then maybe some nut/raison mix I put together"

I eat the same way Carol, that way you get lots of wholesome foods and a good variety. We eat a big lunch, but don't sit down to a big dinner normally. We eat like you - Emma does better eating the way you described too. Except I include mashed potatoes, macaroni and cheese - things like that for her (she 'won't' eat meat yet and rarely accepts chicken either). So I make sure she gets her protein in other ways (beans and eggs for one). When she's a little older things will probably change though. But still, our major meal will always be in the middle of the day.

... also, not grocery shopping when you're hungry is a good idea, and I've learned to do the same thing. The times I've broken that rule, and shopped hungry - well, I shudder thinking about all the extra junk food I bought. I end up have to throw some of it out (after pigging out a few times).

jan said...

Lobie is a bit better this morning. We have left her at this place many times and she has been fine before. We were able to get her outside to pee this morning and she drank some water. She has had stomach ailments before. We are going to get her some chicken and rice and some pepsid AC. that is what the vet gave her in past times for stomach problems. Hope it works again.

Carol said...

Jan, waiting on an afternoon update on the Lobster, AKA Lobie. We also need an update on the Megster, AKA Meg.

Carol said...

Mqw, on TM, seems to be blaming entitlement programs for bankrupting this country. From what I've been learning lately it is the fat cat greedy bankers, Wallstreet guys, bailouts, purchasing worthless shit from the fat cats etc, that has been bankrupting this country. The people who are entitled have paid their hard earned dollars into the system and that's why one day we should be entitled to get something back. Grrrrr.

Carol said...

Seems like someone pushed the wrong button today on Wallstreet. They better lay off the Xanax.